DDEL-06. HEAT-ACTIVATED DOXORUBICIN UPTAKE FACILITATED BY LASER INTERSTITIAL THERMAL THERAPY

Abstract Although surgery has been shown to provide a survival benefit in patients with glioblastoma multiforme (GBM), tumor location and geometry may restrict maximal resection. Additionally, the margin of resection cavity contains infiltrating cells that result recurrence therapy resistance. Laser interstitial thermal (LITT) is treatment modality uses energy destroy cells. LITT useful for tumors are not appropriate conventional surgical Our laboratory developed model study genetically engineered mouse GBM. The combination heat activated nanoparticles represents an opportunity target margin, extending penumbra. We hypothesized heat-activated liposomes containing doxorubicin (ThermoDox, Celsion) would demonstrate infiltration into brain parenchyma after LITT. treated tumor-bearing mice or sham (laser fiber implanted but activated) either ThermoDox (5mg/kg) PBS infusion, 30 minutes before performing treatment. euthanized these 1 hour treatment, harvested brains, performed immunofluorescence identify parenchymal Doxorubicin was identified 100% following administration which contrast groups PBS, ThermoDox, PBS. Here, we show disrupted through hyperthermia followed by release only presence hyperthermia, paves way clinical use as adjunct chemotherapy treatment-resistant GBM